Surgical stress and cancer progression: the twisted tango

Surgical resection is an important avenue for cancer treatment, which, in most cases, can effectively alleviate the patient symptoms. However, accumulating evidence has documented that surgical resection potentially enhances metastatic seeding of tumor cells. In this review, we revisit the literature on surgical stress, and outline the mechanisms by which surgical stress, including ischemia/reperfusion injury, activation of sympathetic nervous system, inflammation, systemically hypercoagulable state, immune suppression and effects of anesthetic agents, promotes tumor metastasis. We also propose preventive strategies or resolution of tumor metastasis caused by surgical stress.

Frontiers Laparoscopic Versus Open Surgery for Early-Stage

Therapeutic regimens to prevent cancer recurrence after surgery

Improved perioperative outcomes and reduced inflammatory stress

Frontiers RIG-1-Like Receptor Activation Synergizes With

PDF) The Impact of Perioperative Events on Cancer Recurrence and

Stresses in the metastatic cascade: molecular mechanisms and

IJMS, Free Full-Text

Simultaneous inhibition of breast cancer and its liver and lung

Surgical stress response and promotion of metastasis in colorectal

Influence of Primary Tumor Resection on Survival of Patients With

Biodegradable electrospun nanofibrous platform integrating

Frontiers The benefits of propofol on cancer treatment: Decipher

Biodegradable electrospun nanofibrous platform integrating