Strategies of cell and cell-free therapies for periodontal regeneration: the state of the art, Stem Cell Research & Therapy
Background Periodontitis often causes irrevocable destruction of tooth-supporting tissues and eventually leads to tooth loss. Currently, stem cell-based tissue engineering has achieved a favorable result in regenerating periodontal tissues. Moreover, cell-free therapies that aim to facilitate the recruitment of resident repair cell populations to injured sites by promoting cell mobilization and homing have become alternative options to cell therapy. Main text Cell aggregates (e.g., cell sheets) retain a large amount of extracellular matrix which can improve cell viability and survival rates after implantation in vivo. Electrostatic spinning and 3D bioprinting through fabricating specific alignments and interactions scaffold structures have made promising outcomes in the construction of a microenvironment conducive to periodontal regeneration. Cell-free therapies with adding biological agents (growth factors, exosomes and conditioned media) to promote endogenous regeneration have somewhat addressed the limitations of cell therapy. Conclusion Hence, this article reviews the progress of stem cell-based tissue engineering and advanced strategies for endogenous regeneration based on stem cell derivatives in periodontal regeneration.
Stem Cell Therapy in Mexico Affordable, Safe and Quality Treatment
JCM, Free Full-Text
Frontiers Hopes and opportunities of stem cells from human exfoliated deciduous teeth (SHED) in cartilage tissue regeneration
Periodontal tissue regeneration by transplantation of autologous adipose tissue-derived multi-lineage progenitor cells
Dentin-Pulp Complex Regeneration
PDF] Mesenchymal Stem Cell Secretome: Toward Cell-Free Therapeutic Strategies in Regenerative Medicine
Regenerative Therapy of Periodontal Tissue
Frontiers Stem Cell Therapy in Chronic Periodontitis: Host Limitations and Strategies
Effective Regenerative Medicine in the United States
Scaffold-free cell-based tissue engineering therapies: advances, shortfalls and forecast
A schematic illustrates the use of stem cell therapy, cell